METABOLIC PHENOTYPING GUIDELINES: Studying eating behaviour in humans

Metabolic Phenotyping Guidelines: studying eating behaviour in humans.

The study of human appetite and eating behaviour has become increasingly important in recent years due to the rise in body weight dysregulation through both obesity and eating disorders. Adequate control over appetite is paramount for the control of body weight and in order to understand appetite, it is necessary to measure eating behaviour accurately. So far, research in this field has reveale...

Metabolic phenotyping guidelines: assessing glucose homeostasis in rodent models.

The pathophysiology of diabetes as a disease is characterised by an inability to maintain normal glucose homeostasis. In type 1 diabetes, this is due to autoimmune destruction of the pancreatic β-cells and subsequent lack of insulin production, and in type 2 diabetes it is due to a combination of both insulin resistance and an inability of the β-cells to compensate adequately with increased ins...

Hereditary deafness and phenotyping in humans.

Hereditary deafness has proved to be extremely heterogeneous genetically with more than 40 genes mapped or cloned for non-syndromic dominant deafness and 30 for autosomal recessive non-syndromic deafness. In spite of significant advances in the understanding of the molecular basis of hearing loss, identifying the precise genetic cause in an individual remains difficult. Consequently, it is impo...

Metabolic Phenotyping of Adipocyte Differentiation

18 19 The 3T3-L1 murine cell line is a robust and widely used model for the study of 20 adipogenesis and processes occurring in mature adipocytes. The fibroblastic like cells 21 can be induced by hormones to differentiate into mature adipocytes. In this study, the 22 metabolic phenotype associated with differentiation of the 3T3-L1 cell line has been 23 studied using gas chromatography-mass spe...

Digital phenotyping and the development and delivery of health guidelines and behaviour change interventions.